BackgroundSH3 Domain-Containing Kinase-Binding Protein 1 (SH3KBP1) contains 3 SH3 domains. SH3KBP1 is widely expressed in many tissues, it is also expressed in some cancer cell lines. SH3KBP1 plays a role in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases. SH3KBP1 is involved in regulation of ligand-dependent endocytosis of the IgE receptor and in the regulation of cellular stress response via the MAPK pathways. SH3KBP1 is also required for the control of cell shape and migration.
FormulationLyophilized from a 0.2 μm filtered solution of 50mM Tris-HCI,10mM reduced Glutathione,pH=8.0.
ALTnamesSH3 Domain-Containing Kinase-Binding Protein 1, CD2-Binding Protein 3, CD2BP3, Cbl-Interacting Protein of 85 kDa, Human Src Family Kinase-Binding Protein 1, HSB-1, SH3KBP1, CIN85