Recombinant Human Fibroblast Growth Factor 23/FGF-23 (C-6His)
Recombinant Human Fibroblast Growth Factor 23 is produced by our Mammalian expression system and the target gene encoding Tyr25-Ile251 is expressed with a 6His tag at the C-terminus. Bon Opus Cat. #CA19
BackgroundFibroblast Growth Factor 23 (FGF-23) is a secreted protein that belongs to the heparin-binding growth factors family. FGF-23 is expressed in osteogenic cells, particularly during phases of active bone remodeling. FGF family members possess broad mitogenic and cell survival activities, involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-23 regulates homeostasis of phosphate and vitamin-D metabolism. FGF-23 inhibits renal tubular phosphate transport by reducing SLC34A1 levels, and negatively regulates osteoblast differentiation and matrix mineralization. FGF-23 also upregulates EGR1 expression in the presence of KL, acts directly on the parathyroid to decrease PTH secretion. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR).
FormulationLyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,1mM EDTA,2mMDTT,pH7.4.
ALTnamesFibroblast Growth Factor 23, FGF-23, Phosphatonin, Tumor-Derived Hypophosphatemia-Inducing Factor, FGF23, HYPF