NeuroD1 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of NeuroD1 on different cells lysates using anti-NeuroD1 antibody at 1/500 dilution.
Line 1: human brain
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IP
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesNeurogenic differentiation factor 1, Class A basic helix-loop-helix protein 3
BackgroundThe basic helix-loop-helix (bHLH) proteins are transcription factors that are required for several aspects of development, including cell type determination, terminal differentiation and sex determination. The HLH domain is required for dimerization, while the basic region makes specific contacts with DNA. Members of the myogenic determination family, MyoD, myf5, myogenin and MRF4, all have bHLH domains. These proteins heterodimerize with members of the E protein family and initiate myogenesis. Neuro D has been identified as a bHLH transcription factor functioning in neurogenic differentiation. Neuro D is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons. Moreover, ectopic expression of Neuro D in Xenopus embryos induces premature differentiation of neuronal precursors and Neuro D can convert presumptive epidermal cells into neurons.(ET1703-73)