Netrin receptor DCC Rabbit polyclonal Antibody IgG

SKU: BA110498-100µl

Fig1: Western blot analysis on Hela using anti- Netrin receptor DCC polyclonal antibody



Bon Opus Cat. #BA110498
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    Immunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Netrin receptor DCC,Colorectal cancer suppressor,Immunoglobulin superfamily DCC subclass member 1,Tumor suppressor protein DCC
  • Background

    Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.(0911-5)

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