N-Cadherin Mouse monoclonal Antibody IgM
Fig1: Western blot analysis on mouse heart (1) and human heart (2) lysates using anti-N-Cadherin mouse mAb.
Fig2: Immunofluorescent staining of A549 cells using anti-N-Cadherin mouse mAb.
Fig3: Immunohistochemical analysis of paraffin- embedded human lung cancer tissue using anti-N-Cadherin mouse mAb.
Host Species; Species ReactivityMouse; Human, Mouse
Application SummaryWB, ICC, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCadherin-2,CDw325,Neural cadherin,CD_antigen: CD325
BackgroundThe cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion.(M1304-1)