MVP Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of MVP on A549 (1) and Hela (2) cell lysate using anti-MVP antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-MVP antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti-MVP antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesMajor vault protein, Lung resistance-related protein
BackgroundMajor vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process.(ET1705-69)