MVP Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of DDAH1 on human kidney (1) and human liver (2) tissue lysate using anti-DDAH1 antibody at 1/1,000 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-DDAH1 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DDAH1 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human
Application SummaryWB, IHC, IP
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesN(G),N(G)-dimethylarginine dimethylaminohydrolase 1, DDAHI, Dimethylargininase-1
BackgroundDDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production. Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation. DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues.(ET1705-71)