Mre11 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of Mre11 on different cells lysates using anti-Mre11 antibody at 1/500 dilution.
Positive control: Line 1: 293T Line 2: Hela
Fig2: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti- Mre11 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue using anti- Mre11 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesDouble-strand break repair protein MRE11, Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog A, Meiotic recombination 11 homolog 1
BackgroundComponent of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.(ET1703-99)