BackgroundTumor Necrosis Factor alpha (TNF-α) is a multifunctional proinflammatory cytokine, mainly secreted by activated macrophages. The cytokine was named for its remarkable ability to cause hemorrhagic necrosis of tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. It is well documented that TNF-a functions through its receptors, TNFR1 (p55) and TNFR2 (p75).
ALTnamesTumor necrosis factor, TNFa, TNFalpha, TNFα, tnf a, tnf alpha, tnf α, cachectin, TNFSF2, TNSF 2