BackgroundInterleukin 1 (IL-1) is first cytokine super-family identified during the early research on cell secreted factors that regulator fever and inflammatory reaction. IL-1 is also known as lymphocyte activating factor, endogenous pyrogen, catabolin, hemopoietin-1, melanoma growth inhibition factor, and osteoclast activating factor. The properties and biological activities of IL-1 have been extensively reviewed. The two most studied members in the family are Interleukin 1α (IL-1α) and Interleukin 1β(IL-1β). IL-1α (also known as IL-1F1) and IL-1β(also known as IL-1F2) are distinct gene products, but they recognize the same receptors and have similar biological properties. A natural antagonist of IL-1α and IL-1β called IL-1Ra was found to compete with IL-1α and IL-1β for membrane receptor binding to down-regulate the activity of IL-1α and IL-1β.
ALTnamesInterleukin 1b, Interleukin 1beta, Interleukin 1 beta, , interleukin 1β, IL1b, IL 1b, IL1beta, IL 1beta, IL 1 beta, IL1β, il 1β