• Background

    IL-1α is a member of interleukin 1 family. IL-1α and IL-1β recognize the same IL-1 receptor and share a number of similar biological functions. IL-1α is predominantly a cell-associated molecule whereas IL-1β is a secreted molecule. IL-1α is synthesized primarily as a precursor that is biologically active via specific cell binding. Precursor IL-1α can be cleaved by extracellular proteases when the cells die, and can also be cleaved by activation of the calcium-dependent, membrane-associated calpains. Cleavage of the mouse IL-1α precursor results in an 18 kDa mature mouse IL-1αmolecule.
  • ALTnames

    Interleukin 1a, interleukin 1alpha, interleukin 1 alpha, interleukin 1α, IL1a, IL 1a, IL1alpha, IL 1alpha, IL 1 alpha, IL1α, IL 1α

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