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Mouse anti-Thr181 Phosphorylated Tau Monoclonal Antibody, Clone 7G9

SKU: BA010329-100µl
$279.00Price

Fig1: Western blot analysis; the antibody detected a 46kD band in mouse brain tissue lysate. (Cat. #:MO-MO-M40099B).

Bon Opus Cat. #BA010329
Size
  • Host Species; Species Reactivity

    Mouse; Human, mouse.

  • Immunogen

    KLH conjugated with a short peptide [Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys], corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein.

  • Application Summary

    WB, ELISA

  • Purification

    Protein G affinity purified

  • Formulation

    Lyophilized from a solution in 0.01M PBS pH7.2

  • Background

    Tau is a highly soluble microtubule associated protein found in high concentration in neuron of central nervous system. The main function of the protein is stabilizing the microtubule in nerve fibre (axon). There are six tau isoforms which are formed by alternate splicing. Hyperphosphorylation of Tau protein results in aggregation and formation of neurofibrillary tangles, which is significantly associated with cognitive impairment in Alzheimer’s disease. Tau Thr181 phosphorylation has been used as a biomarker for the differentiation of Alzheimer’s disease and other primary dementia such as dementia with Lewy bodies.