MMP2 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of MMP2 on human MMP2 recombinant protein using anti-MMP2 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of MMP2 on HEK293 (1) and MMP2-hIgGFc transfected HEK293 (2) cell lysate using anti-MMP2 antibody at 1/1,000 dilution.
Fig3: Western blot analysis of MMP2 on different cell lysate using anti-MMP2 antibody at 1/1,000 dilution.
Lane 1: MCF-7
Lane 2: Raw264.7
Lane 3: HUVEC
Lane 4: T47D
Host Species; Species ReactivityMouse; Human, Mouse
Application SummaryWB, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundThe matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV, V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.(EM1706-99)