MMP14 Mouse monoclonal Antibody IgG1

MMP14 Mouse monoclonal Antibody IgG1

SKU: BA112727-100µl

Fig1: Western blot analysis of MMP14 on human MMP14 recombinant protein using anti-MMP14 antibody at 1/1,000 dilution.

Fig2: Western blot analysis of MMP14 on HEK293 (1) and MMP14-hIgGFc transfected HEK293 (2) cell lysate using anti-MMP14 antibody at 1/1,000 dilution.

Fig3: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using anti-MMP14 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112727
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    GTP-binding protein Ram
  • Background

    The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. Membrane-type matrix metalloproteinases, including MT-MMP-1 (also designated MMP-14), MT-MMP-2 (also designated MMP-15), MT-MMP-3 (also designated MMP-16) and MT-MMP-4 (also designated MMP-17) are type I membrane proteins that function to activate other MMPs. MT-MMP activation appears to be mediated by members of the proprotein convertase family, suggesting that a proprotein convertase/MT-MMP/MMP cascade may be involved in the regulation of ECM turnover.(EM1706-30)

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