MMP12 Recombinant Rabbit monoclonal Antibody IgG

MMP12 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111351-100µl

Fig1: Western blot analysis of MMP12 on different cell lysates using anti-MMP12 antibody at 1/1,000 dilution.

Positive control: 

  Lane 1: A549 

  Lane 2: Hela 

  Lane 3: MCF-7 

  Lane 4: THP-1

Fig2: Immunohistochemical analysis of paraffin-embedded human breast carcinomna tissue using anti-MMP12 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-MMP12 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111351
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Macrophage metalloelastase, Macrophage elastase, Matrix metalloproteinase-12
  • Background

    The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-12 (also designated macrophage metalloelastase) is produced in alveolar macrophages and degrades elastin. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.(ET1602-42)

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