MASP2 Mouse monoclonal Antibody IgG2b
Fig1: Western blot analysis on human serum lysates using anti-MASP2 mouse mAb.
Host Species; Species ReactivityMouse; Human
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesX-ray repair cross-complementing protein 6,5'-deoxyribose-5-phosphate lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Thyroid-lupus autoantigen,X-ray repair complementing defective repair in Chinese hamster cells 6
BackgroundMannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene. MASP-2 involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.(M1501-11)