MAPK14 Mouse monoclonal Antibody IgG2a

MAPK14 Mouse monoclonal Antibody IgG2a

SKU: BA110454-100µl

Fig1: Western blot analysis of MAPK14 on different cell lysates using anti-MAPK14 antibody at 1/500 dilution.

Positive control:   

Lane 1: A431         

Lane 2: HepG2 

Lane 3: Hela         

Lane 4: NIH/3T3 

Lane 5: Jurkat       

Lane 6: 293T 

Lane 7: mouse placenta

Fig2: ICC staining of MAPK14 in Hela cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using anti-MAPK14 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA110454
  • Host Species; Species Reactivity

    Mouse; Human, Mouse
  • Immunogen

  • Application Summary

    WB, ICC, IHC
  • Purification; Formulation

    ProG affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Mitogen-activated protein kinase 14,Cytokine suppressive anti-inflammatory drug-binding protein,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,Stress-activated protein kinase 2a
  • Background

    Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related transcription and cell cycle regulation, as well as in genotoxic stress response.(EM40307)

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