LY6A Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of LY6A on mouse brain cells lysates using anti-LY6A antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded brain mouse tissue using anti-LY6A antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-LY6A antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Mouse
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesLymphocyte antigen 6A-2/6E-1, Stem cell antigen 1, T-cell-activating protein
BackgroundThe activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily. The Ly-6 alloantigens represent a family of phosphatidylinositol anchored proteins that play a role in the process of T lymphocyte activation. Ly-6 expression is commonly induced on T and B lymphocytes after activation by mitogens. Ly-6A/E is a phosphatidylinositol-linked transmembrane member of the Ly-6 family that is produced in humans after 4 weeks of age. γ-interferon and TNF regulate Ly-6A/E at the level of transcription and mRNA stabilization in certain thymocytes and T-cells.(ET1703-67)