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LRP1 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111284-100µl
$279.00Price

Fig1: Western blot analysis of LRP1 on different lysates using anti-LRP1 antibody at 1/1,000 dilution.

Positive control: 

  Lane 1: Mouse liver 

  Lane 2: Mouse brain  Lane 

  Lane 3: Mouse lung 

  Lane 4: Human liver 

  Lane 5: HepG2 

  Lane 6: Human lung

Fig2: ICC staining LRP1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: ICC staining LRP1 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Bon Opus Cat. #BA111284
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC/IF, IHC, IP, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Prolow-density lipoprotein receptor-related protein 1, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, CD_antigen: CD91
  • Background

    Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and a-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including a-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer’s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.(ET1601-1)