LMNB2 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis of Lamin B2 on different cell lysates using anti-LMNB2 antibody at 1/1000 dilution.
Lane 1: Hela
Lane 3: HepG2
Fig2: ICC staining of LMNB2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: ICC staining of LMNB2 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, ICC, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundLamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Defects in LMNB2 are a cause of partial acquired lipodystrophy (APLD), which is a rare childhood disease characterized by loss of subcutaneous fat from the face and trunk.(ER0403)