LinkLight™ U2-OS EDNRB / β-arrestin Cell Line
LinkLight™ U2-OS EDNRB / β-arrestin Cell Line is a stable monoclonal cell line in U2-OS cells, targeting Human EDNRB pathway via b-arrestin. The proprietary LinkLight™ technology uses a standard Luciferase Assay as the detection method. Bon Opus Cat. #BC050026
BackgroundEDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
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