Host Species; Species ReactivityRabbit; Human
Application SummaryWB, ICC, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesX-ray repair cross-complementing protein 6,5'-deoxyribose-5-phosphate lyase Ku70,70 kDa subunit of Ku antigen，ATP-dependent DNA helicase 2 subunit 1，ATP-dependent DNA helicase II 70 kDa subunit，CTC box-binding factor 75 kDa subunit,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Thyroid-lupus autoantigen,X-ray repair complementing defective repair in Chinese hamster cells 6
BackgroundTogether, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.(R1401-5)