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Ku70 Mouse monoclonal Antibody IgG2a

SKU: BA110422-100µl
$279.00Price

Fig1: Western blot analysis of Ku70 on different cell lysates using anti-Ku70 antibody at 1/2000 dilution.

Positive control:   

Lane 1: Hela              

Lane 2: HepG2 

Lane 3: A431             

Lane 4: D3 

Lane 5: 293T             

Lane 6: A549 

Lane 7: COS-1           

Lane 8: Human kidney 

Lane 9: Human liver     

Lane 10: human brain 

Lane 11: Human thymus   

Lane 12: Human placentae 

Lane 13: Mouse kidney   

Lane 14: Mouse liver 

Lane 15: Mouse thymus   

Lane 16: Mouse testis

Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Ku70 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-Ku70 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA110422
Size
  • Host Species; Species Reactivity

    Mouse; Human, Mouse
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    X-ray repair cross-complementing protein 6,5'-deoxyribose-5-phosphate lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Thyroid-lupus autoantigen,X-ray repair complementing defective repair in Chinese hamster cells 6
  • Background

    Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system.In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein.(EM50109)