KCND2 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of Kv4.2 on human Kv4.2 recombinant protein using anti- Kv4.2 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of Kv4.2 on HEK293 (1) and Kv4.2-hIgGFc transfected HEK293 (2) cell lysate using anti- Kv4.2 antibody at 1/1,000 dilution.
Fig3: Flow cytometric analysis of Hela cells with Kv4.2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
Host Species; Species ReactivityMouse; Human
Application SummaryWB, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesRho-related GTP-binding protein RhoF, Rho family GTPase Rif, Rho in filopodia
BackgroundVoltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. The KV gene family encodes more than 30 genes that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution, and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming α-subunits (KVα), which include the KV1, KV2, KV3, and KV4 proteins, and accessory or KVβ subunits that modify the gating properties of the coexpressed KVα subunits. Differences exist in the patterns of trafficking, biosynthetic processing and surface expression of the major KV1 subunits (KV1.1, KV1.2, KV1.4, KV1.5 and KV1.6) expressed in rat and human brain, suggesting that the individual protein subunits are highly regulated to control for the assembly and formation of functional neuronal channels.(EM1706-51)