KBTBD8 Mouse monoclonal Antibody IgG1
Fig1: Western blot analysis of KBTBD8 on human KBTBD8 recombinant protein using anti-KBTBD8 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of KBTBD8 on HEK293 (1) and KBTBD8-hIgGFc transfected HEK293 (2) cell lysate using anti-KBTBD8 antibody at 1/1,000 dilution.
Fig3: Western blot analysis of KBTBD8 on different cell lysate using anti-KBTBD8 antibody at 1/1,000 dilution.
Positive control: Line1: A431 Line2: Jurkat Line3: Hela Line4: K562 Line5: Hek293
Host Species; Species ReactivityMouse; Human
Application SummaryWB, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesHistone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Histone acetyltransferase HTATIP, Lysine acetyltransferase 5, cPLA(2)-interacting protein
BackgroundSubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.(EM1706-50)