JNK1+JNK2+JNK3 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111304-100µl
$279.00Price

Fig1: Western blot analysis of JNK1+JNK2+JNK3 on different cell lysates using anti-JNK1+JNK2+JNK3 antibody at 1/1,000 dilution.

Positive control: 

  Lane 1: Hela 

  Lane 2: PC12 

  Lane 3: K562 

  Lane 5: HepG2 

  Lane 6: Human lung

Fig2: ICC staining JNK1+JNK2+JNK3 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: Western blot analysis of JNK1+JNK2+JNK3 on hybrid  fish (crucian-carp) brain tissue lysate using anti-JNK1+JNK2+JNK3 antibody at 1/500 dilution.

Bon Opus Cat. #BA111304
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat, Cow, Monkey, Zebrafish
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC/IF, IP
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Mitogen-activated protein kinase 8, Mitogen-activated protein kinase 9, Mitogen-activated protein kinase 10
  • Background

    c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.(ET1601-28)

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