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Jagged1 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112066-100µl

Fig1: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Jagged1 antibody. Counter stained with hematoxylin.

Fig2: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Jagged1 antibody. Counter stained with hematoxylin.


Bon Opus Cat. #BA112066
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Protein jagged-1, CD_antigen: CD339
  • Background

    The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and expression is upregulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the Jagged1 gene.(ET1702-63)