Integrin beta 1 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111292-100µl
$279.00Price

Fig1: Western blot analysis of Integrin beta 1 on different cell lysates using anti-Integrin beta 1 antibody at 1/1,000 dilution.

Positive control: 

  Lane 1: Hela 

  Lane 2: NIH/3T3

Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Integrin beta 1 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111292
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat, Zebrafish
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein Iia, VLA-4 subunit beta, CD_antigen: CD29
  • Background

    Integrins are transmembrane receptors that mediate the attachment between a cell and its surroundings, such as other cells or the extracellular matrix (ECM). Integrins are obligate heterodimers containing two distinct chains, called the α (alpha) and β (beta) subunits. The molecular mass of the integrin subunits can vary from 90 kDa to 160 kDa. Beta subunits have four cysteine-rich repeated sequences. Both α and β subunits bind several divalent cations. Integrins have two main functions: Attachment of the cell to the ECM and signal transduction from the ECM to the cell. However, they are also involved in a wide range of other biological activities, including immune patrolling, cell migration, and binding to cells by certain viruses, such as adenovirus, echovirus, hantavirus, and foot and mouth disease viruses. Research studies have implicated β1 integrin in various activities including embryonic development, blood vessel, skin, bone, and muscle formation, as well as tumor metastasis and angiogenesis.(ET1601-17)

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