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Integrin beta-1 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA111316-100µl
$279.00Price

Fig1: Western blot analysis of Integrin beta-1 on human liver lysates using anti-Integrin beta-1 antibody at 1/1,000 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Integrin beta-1 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Integrin beta-1 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA111316
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein Iia, VLA-4 subunit beta, CD_antigen: CD29
  • Background

    Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.(ET1602-10)