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IL1 alpha Rabbit polyclonal Antibody IgG

SKU: BA111049-100µl
$279.00Price

Fig1: Western blot analysis of IL1 alpha on human lymph node lysates using anti-IL1 alpha antibody at 1/500 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-IL1 alpha antibody. Counter stained with hematoxylin.

Fig3: Flow cytometric analysis of PC-3M cells with IL1 alpha antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.

Bon Opus Cat. #BA111049
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse
  • Immunogen

    Recombinant protein
  • Application Summary

    IHC,FC,WB
  • Purification; Formulation

    Protein affinity purified; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Interleukin-1 alpha, Hematopoietin-1
  • Background

    Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1β for production of the anti- pathogen IFN-γ. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.(ER1802-36)