Ikk alpha Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis of IKK alpha on different cell lysates using anti-IKK alpha antibody at 1/500 dilution.
Lane 1: Hela
Lane 2: HepG2
Lane 3: Raji
Lane 4: NIH/3T3
Lane 5: PC12
Lane 6: Jurkat
Fig2: ICC staining IKK alpha in N2A cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human mammary gland tissue using anti-IKK alpha antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, ICC, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesInhibitor of nuclear factor kappa-B kinase subunit alpha,Conserved helix-loop-helix ubiquitous kinase,I-kappa-B kinase 1,Nuclear factor NF-kappa-B inhibitor kinase alpha,Transcription factor 16
BackgroundSerine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. It acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.(ER30911)