IKB epsilon Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of IKB epsilon on different cell lysate using anti-IKB epsilon antibody at 1/1,000 dilution.
Line 1: THP-1 Line 2: Jurkat Line 3: Hela
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-IKB epsilon antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human
Application SummaryWB, IHC, IP
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesNF-kappa-B inhibitor epsilon, I-kappa-B-epsilon
BackgroundOn the basis of both functional and structural considerations, members of the IκB family of proteins can be divided into four groups. The first of these groups, IκB-α, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50-p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to κB sites, suggesting that the IκB-α family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IκB family is represented by a protein designated IκB-β. The third group of IκB proteins is represented by IκB-γ, which is identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and is expressed predominantly in lymphoid cells. An additional IκB family member, IκB-ε, has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel.(ET1705-40)