IGFBP2 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of IGFBP2 on Human serum (1) and NCCIT (2) lysates using anti-IGFBP2 antibody at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-IGFBP2 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesInsulin-like growth factor-binding protein 2
BackgroundThe Insulin-like growth factor-binding proteins (IGFBPs), a family of homologous proteins that have co-evolved with the IGFs, serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, and their concentration and distribution in the extracellular environment. The IGFBPs also appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP1 is negatively regulated by Insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. IGFBP2, which may function as a chaperone, escorting IGFs to their target tissues, is expressed in several human tissues including fetal eye and fetal brain.(ET7106-63)