IGF2R/M6PR Rabbit polyclonal Antibody IgG
Fig1: Immunocytochemical staining of Hela cells using anti-M6PR rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of SW480 cells using anti-M6PR rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of MCF-7 cells using anti-M6PR rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human
Application SummaryICC, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesCation-independent mannose-6-phosphate receptor,300 kDa mannose 6-phosphate receptor,Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor,M6P/IGF2 receptor,CD_antigen: CD222
BackgroundThe mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.(R1510-3)