IGF2R/M6PR Rabbit polyclonal Antibody IgG

SKU: BA110388-100µl

Fig1: Immunocytochemical staining of Hela cells using anti-M6PR rabbit polyclonal antibody.

Fig2:  Immunocytochemical staining of SW480 cells using anti-M6PR rabbit polyclonal antibody.

Fig3:  Immunocytochemical staining of MCF-7 cells using anti-M6PR rabbit polyclonal antibody.

Bon Opus Cat. #BA110388
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Cation-independent mannose-6-phosphate receptor,300 kDa mannose 6-phosphate receptor,Insulin-like growth factor 2 receptor,Insulin-like growth factor II receptor,M6P/IGF2 receptor,CD_antigen: CD222
  • Background

    The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.(R1510-3)

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