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IGF1R Rabbit polyclonal Antibody IgG

SKU: BA110387-100µl
$279.00Price

Fig1:  Western blot analysis on cell lysates using anti- IGF1R rabbit polyclonal antibodies.

Fig2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti- IGF1R rabbit polyclonal antibody.

 

Bon Opus Cat. #BA110387
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Peptide
  • Application Summary

    WB, IHC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Insulin-like growth factor 1 receptor,Insulin-like growth factor I receptor,CD_antigen: CD221
  • Background

    Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell lines and cell types within fetal and postnatal tissues. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis.(R1310-6)