Hsp90 alpha Rabbit polyclonal Antibody IgG

SKU: BA110365-100µl
$279.00Price

Fig1: Western blot analysis on different cell lysates using anti-HSP90 alpha rabbit polyclonal antibody. Positive control: 

Lane 1: Hela       

Lane 2: 293T 

Lane 3: PC-12      

Lane 4: NIH/3T3

Fig2:  Immunocytochemical staining of HepG2 cells using anti-HSP90 alpha rabbit polyclonal antibody.

Fig3:  Immunocytochemical staining of C2C12 cells using anti-HSP90 alpha rabbit polyclonal antibody.

Bon Opus Cat. #BA110365
Size
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Peptide
  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Heat shock protein HSP 90-alpha,Heat shock 86 kDa,Lipopolysaccharide-associated protein 2,Renal carcinoma antigen NY-REN-38
  • Background

    The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.(R1510-29)

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