HSD11B1 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112404-100µl

Fig1: Western blot analysis of HSD11B1 on mouse liver tissue lysate using anti-HSD11B1 antibody at 1/500 dilution.

Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-HSD11B1 antibody. Counter stained with hematoxylin.

Fig3: Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-HSD11B1 antibody. Counter stained with hematoxylin.

Bon Opus Cat. #BA112404
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

    Recombinant protein
  • Application Summary

  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Corticosteroid 11-beta-dehydrogenase isozyme 1, 11-beta-hydroxysteroid dehydrogenase 1, Short chain dehydrogenase/reductase family 26C member 1
  • Background

    HSD11B1(Corticosteroid 11-beta-dehydrogenase isozyme 1) is also named as HSD11, HSD11L,11-DH and 11-beta-HSD1.It is a microsomal enzyme, which acts mainly as a NADP(H)- dependent reductase converting inactive cortisone (E) to active cortisol (F), thus regulating intracellular F access to glucocorticoid receptor. This enzyme is widely expressed not only in liver and adipose tissue, but also in adrenal, ovary and decidua.Western blot analysis in human liver, using a specific11-beta-HSD1 antibody, showed two bands at approximately 34 and 68 kDa confrming the dimeric nature of 11-beta-HSD1 in liver and In omental adipose tissue, an additional band of 50 kDa was strongly expressed.(ET1706-27)

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