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HPRT1 Mouse monoclonal Antibody IgG1

SKU: BA112728-100µl
$279.00Price

Fig1: Western blot analysis of HPRT1 on human HPRT1 recombinant protein using anti-HPRT1 antibody at 1/1,000 dilution.

Fig2: Western blot analysis of HPRT1 on HEK293 (1) and HPRT1-hIgGFc transfected HEK293 (2) cell lysate using anti-HPRT1 antibody at 1/1,000 dilution.

Fig3: Western blot analysis of HPRT1 on different cell lysate using anti-HPRT1 antibody at 1/1,000 dilution.

Bon Opus Cat. #BA112728
Size
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, IHC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Caveolin-2
  • Background

    HPRT (hypoxanthine phosphoribosyltransferase 1), also known as HGPRT or HPRT1, is a 218 amino acid cytoplasmic protein that belongs to the purine/pyrimidine phosphoribosyltransferase family. Involved in purine metabolism, HPRT functions as a purine salvage enzyme that catalyzes the conversion of hypoxathine and guanine to their respective mononucleotides (inosine monophosphate and guanosine monophosphate, respectively). HPRT exists as a homotetramer that can bind two magnesium ions as cofactors. Defects in the gene encoding HPRT are the cause of gout and Lesch-Nyhan syndrome (LNS), both of which are characterized by a partial or complete lack of NPRT enzymatic activity. While a partial loss of HPRT enzymatic activity results in a buildup of uric acid (gout), a total loss of enzymatic activity results in hyperuricaemia, mental retardation, choreoathetosis and compulsive self-mutilation, all of which are symptoms associated with LNS. The severity of these diseases suggests an essential role for HPRT in purine metabolism.(EM1706-31)