HOXB4 Mouse monoclonal Antibody IgG2a
Fig1: Western blot analysis of HOXB4 on human HOXB4 recombinant protein using anti-HOXB4 antibody at 1/1,000 dilution.
Fig2: Western blot analysis of HOXB4 on HEK293 (1) and HOXB4-hIgGFc transfected HEK293 (2) cell lysate using anti-HOXB4 antibody at 1/1,000 dilution.
Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-HOXB4 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityMouse; Human
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesDesmoglein-3, 130 kDa pemphigus vulgaris antigen, Cadherin family member 6
BackgroundThe homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Encoded by the HOXB4 gene, the nuclear phosphoprotein HoxB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation. Hematopoietic expression of HoxB4 is regulated by the binding of USF-1 and USF-2, the binding of which may be favored by cytokines promoting stem cell self-renewal versus differentiation. HoxB4 is dependent on AP-1 expression to induce changes in cellular proliferation and differentiation, which increases the levels of cyclin D1, thereby linking HoxB4 with key elements of the cell cycle machinery. HoxB4 also participates in the down-regulation of c-Myc expression. It is expressed in developing hair follicles as well as in K-562 and HL-60 cells.(EM1706-5)