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HDAC4 Mouse monoclonal Antibody IgG1

SKU: BA112699-100µl
$279.00Price

Fig1: Western blot analysis of HDAC4 on human HDAC4 recombinant protein using anti-HDAC4 antibody at 1/1,000 dilution.

Fig2: Western blot analysis of HDAC4 on HEK293 (1) and HDAC4-hIgGFc transfected HEK293 (2) cell lysate using anti-HDAC4 antibody at 1/1,000 dilution.

Fig3: ICC staining HDAC4 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Bon Opus Cat. #BA112699
Size
  • Host Species; Species Reactivity

    Mouse; Human
  • Immunogen

    Recombinant protein
  • Application Summary

    WB, ICC, FC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Ras-related protein Rab-3A
  • Background

    In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, p300/CBP, PCAF (p300/CBP associated factor), HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.(EM1706-2)