GSK3 beta Rabbit polyclonal Antibody IgG
Fig1: Immunocytochemical staining of SHG-44 cells using anti-GSK3 beta rabbit polyclonal antibody.
Fig2: Immunocytochemical staining of MCF-7 cells using anti-GSK3 beta rabbit polyclonal antibody.
Fig3: Immunocytochemical staining of SW480 cells using anti-GSK3 beta rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryICC, IHC, FC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesGlycogen synthase kinase-3 beta,Serine/threonine-protein kinase GSK3B
BackgroundGlycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer’s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer’s disease.(R1510-4)