GRP78 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on cell lysates using anti-GPR78 rabbit polyclonal antibodies.
Fig2: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti- GPR78 rabbit polyclonal antibody.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
Application SummaryWB, ICC, IHC, FC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnames78 kDa glucose-regulated protein,Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78，Heat shock 70 kDa protein 5，Immunoglobulin heavy chain-binding protein
BackgroundBinding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, and maintains them in a state competent for subsequent folding and oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. Like many stress and heat shock proteins, BiP/GRP78 has potent immunological activity when released from the internal environment of the cell into the extracelluar space.specifically, it feeds anti-inflammatory and pro-resolutory signals into immune networks, thus helping to resolve inflammation.(R1401-26)