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©2020 by Bon Opus Biosciences, LLC.

Grp75 Mouse monoclonal Antibody IgG1

SKU: BA110869-100µl
$279.00Price

Fig1: Western blot analysis of Grp75 on different cell lysates using anti-Grp75 antibody at 1/1,000 dilution.

  Positive control:

 Lane 1: NIH-3T3

         Lane 2: HepG2

   Lane 3: K562 

           Lane 4: L929 

 

Fig2: ICC staining Grp75 (green) in A549 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: ICC staining Grp75 (green) in HepG2 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Bon Opus Cat. #BA110869
Size
  • Host Species; Species Reactivity

    Mouse; Human, Mouse, Rat
  • Immunogen

    Peptide
  • Application Summary

    WB,IHC,ICC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Stress-70 protein, mitochondrial, 75 kDa glucose-regulated protein, Heat shock 70 kDa protein 9, Mortalin, Peptide-binding protein 74
  • Background

    The HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. HSC 70, GRP 75 and GRP 78 are constitutively expressed in primate cells. HSP 70 expression is strongly induced in response to heat stress. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation.(EM1701-23)