GPX4 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of GPX4 on different lysates using anti-GPX4 antibody at 1/500 dilution.
Lane 1: Rat liver
Lane 2: Mouse kidney
Lane 3: Human liver
Lane 4: Jurkat
Fig2: Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-GPX4 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-GPX4 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat, Zebrafish
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesPhospholipid hydroperoxide glutathione peroxidase, mitochondrial, Glutathione peroxidase 4
BackgroundGlutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1-8). GPx-1, Gpx-2 and Gpx-3 exist as homotetramers. Gpx-4 has a high tendancy to form high molecular weight oligomers.(ET1706-45)