Glucose Transporter GLUT4 Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on cell lysates using anti-GLUT4 rabbit polyclonal antibodies.
Fig2: ICC staining GLUT4 in MCF-7 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-GLUT4 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse
Application SummaryWB, ICC/IF, IHC
Purification; FormulationPeptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesSolute carrier family 2, facilitated glucose transporter member 4,Glucose transporter type 4, insulin-responsive
BackgroundGLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac) that is responsible for insulin-regulated glucose transport into the cell. Under conditions of low insulin, GLUT4 is sequestered in intracellular vesicles in muscle and fat cells. Insulin induces a rapid increase in the uptake of glucose by inducing the translocation of GLUT4 from these vesicles to the plasma membrane. Muscle contraction stimulates muscle cells to translocate GLUT4 receptors to their surfaces. This is especially true in cardiac muscle, where continuous contraction can be relied upon; but is observed to a lesser extent in skeletal muscle.(R1402-3)