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Gli3 Recombinant Rabbit monoclonal Antibody IgG

SKU: BA112627-100µl
$279.00Price

Fig1: Western blot analysis of Gli3 on PC-3M cell lysate using anti-Gli3 antibody at 1/1,000 dilution.

 

 

Bon Opus Cat. #BA112627
Size
  • Host Species; Species Reactivity

    Rabbit; Human
  • Immunogen

    Recombinant protein within human Gli3 aa 1300-1600.
  • Application Summary

    WB,ICC
  • Purification; Formulation

    ProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3 full-length protein, Transcriptional repressor GLI3R, GLI3 C-terminally truncated form, GLI3 form of 83 kDa
  • Background

    Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-3 (GLI family zinc finger 3), also known as GLI3FL (GLI3 full length protein), PHS, ACLS, GCPS, PAPA, PAPB, PAPA1 or PPDIV, is a 1,580 amino acid nuclear and cytoplasmic protein that acts as both a transcriptional activator and a repressor of the Sonic hedgehog (Shh) pathway. A member of the GLI C2H2-type zinc-finger protein family, GLI-3 is encoded by a gene that maps to human chromosome 7p14.1. Defects in the GLI-3 gene are the cause of a disorder known as Greig cephalo-poly-syndactyly syndrome (GCPS), which affects limb and craniofacial development.(ET7108-68)