Geminin Rabbit polyclonal Antibody IgG
Fig1: Western blot analysis on Hela cell lysates using anti-Geminin rabbit polyclonal antibody.
Fig2: ICC image of Geminin antibody stained NCCIT cells. The secondary antibody (green) was goat anti-rabbit IgG (H+L) FITC conjugated.
Fig3: ICC image of Geminin antibody stained F9 cells. The secondary antibody (green) was goat anti-rabbit IgG (H+L) FITC conjugated.
Host Species; Species ReactivityRabbit; Human, Mouse
Application SummaryWB, ICC, FC
Purification; FormulationImmunogen affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
BackgroundGeminin is a nuclear protein that is present in most eukaryotics and highly conserved across species. Numerous functions have been elucidated for Geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. During S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNAi results in re-replication of portions of the genome, which leads to aneuploidy.(R1204-2)