Gemin 1 Recombinant Rabbit monoclonal Antibody IgG
Fig1: Western blot analysis of Gemin 1 on SiHa cell lysates using anti-Gemin 1 at 1/500 dilution.
Fig2: Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-Gemin 1 antibody. Counter stained with hematoxylin.
Fig3: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Gemin 1 antibody. Counter stained with hematoxylin.
Host Species; Species ReactivityRabbit; Human, Mouse, Rat
ImmunogenRecombinant protein within human Gemin 1 aa 1-200.
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesSurvival motor neuron protein, Component of gems 1, Gemin-1
BackgroundThe SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).(ET7108-63)