Host Species; Species ReactivityMouse; Human
Application SummaryWB, IHC
Purification; FormulationProA affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
ALTnamesTranscription factor GATA-4,GATA-binding factor 4
BackgroundGATA4 is a transcriptional activator expressed in heart, intestine, liver, primative endoderm and gonads. It binds to the consensus sequence 5'-AGATAG-3' and regulates the expression of the HSP47/J6 gene in F9 cells. GATA4 acts as a transcriptional activator of ANF in cooperation with NKX2-5. Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2).(M1306-2)