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GAP43 Rabbit polyclonal Antibody IgG

SKU: BA110288-100µl

Fig1: Western blot analysis of GAP43 on different cell lysates using anti-GAP43 antibody at 1/1000 dilution.

Positive control:

Lane 1: Rat brain

Lane 2: Mouse brain

Lane 3: Mouse heart

Lane 4: Human skeletal muscle

Lane 5: N2A

Lane 6: A172

Lane 7: Human heart

Fig2: ICC staining GAP43 in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Fig3: ICC staining GAP43 in NIH/3T3 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Bon Opus Cat. #BA110288
  • Host Species; Species Reactivity

    Rabbit; Human, Mouse, Rat
  • Immunogen

  • Application Summary

    WB, ICC, IHC, FC
  • Purification; Formulation

    Peptide affinity purified; 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.; Liquid form.
  • ALTnames

    Neuromodulin,Axonal membrane protein GAP-43,Calmodulin-binding protein P-57,Growth-associated protein 43
  • Background

    GAP43, is a nervous tissue-specific cytoplasmic protein that can be attached to the membrane via a dual palmitoylation sequence on cysteines 3 and 4. This sequence targets GAP43 to lipid rafts. It is a major protein kinase C (PKC) substrate and is considered to play a key role in neurite formation, regeneration, and plasticity. The role of GAP-43 in CNS development is not limited to effects on axons: It is also a component of the centrosome, and differentiating neurons that do not express GAP-43 show mislocalization of the centrosome and mitotic spindles, particularly in neurogenic cell divisions. As a consequence, in the cerebellum, the neuronal precursor pool fails to expand normally and the cerebellum is significantly smaller.(ER40201)